The phosphatidylinositol signalling pathway in human cancer
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چکیده
منابع مشابه
The mTOR Signalling Pathway in Human Cancer
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BACKGROUND The phosphatidylinositol 3-kinase (PI3K)/Akt signalling pathway plays a major role in the regulation of breast cancer growth and survival, but the clinical value of its components in human tumours is unclear. PATIENTS AND METHODS PI3K was analysed using Western blotting with monoclonal antibodies to the p85 subunit in tumour and adjacent mammary gland samples from 33 breast cancer ...
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The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) network plays a key regulatory function in cell survival, proliferation, migration, metabolism, angiogenesis, and apoptosis. Genetic aberrations found at different levels, either with activation of oncogenes or inactivation of tumor suppressors, make this pathway one of the most commonly disrupted in human breast ...
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ژورنال
عنوان ژورنال: Drug Delivery System
سال: 2003
ISSN: 1881-2732,0913-5006
DOI: 10.2745/dds.18.351